DD-study: diet or diuretics for salt-sensitivity in chronic kidney disease - DD-study

未提供0 个研究点开始时间: 2015年9月22日最近更新: 2016年4月11日

试验速览

暂无简介。

•- Age > 18 years.
•- Chronic kidney disease stage 3 or 4 (MDRD-GFR 15-60 ml/min)
•- Use of any anti-hypertensive drugs
•- No anti-hypertensive drugs but an average office systolic blood pressure > 140 mmHg (as measured by datascope)
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 14
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•- Salt-wasting chronic kidney disease
•- Nephrotic syndrome
•- Pregnant or breastfeeding women
•- Life expectancy < 6 months
•- Severe heart failure (NYHA III or IV) or liver cirrhosis with ascites and the inability to withdraw diuretics
•- Rapidly declining kidney function with high likelihood of dialysis or kidney transplantation in the coming 4 months
•- Kidney transplant recipients
•- Use of immunosuppressive drugs
•- Use of non-steroidal anti-inflammatory drugs
•- Previous intolerance or allergy to hydrochlorothiazide or amiloride
•- Serum sodium < 135 mmol/l
•- Serum potassium < 3.5 mmol/l or > 5.0 mmol/l
•- Inability to adhere to the study protocol (due to language, incapacitated subjects, subjects with intellectual disability)

发起方

未提供