NCT00978640Unknown不适用
Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise
适应症
干预措施
试验速览
- 阶段
- 不适用
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Sirt1 activity
研究概览
简要总结
Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).
Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.
In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy men
- •Body mass index (BMI) 20-26
- •age 18-45 years
排除标准
- •any kind of disease
- •any use of medicine
研究组 & 干预措施
fasting and exercise
Experimental
36 h fast and 1 h ergometer cycling 50% VO2max
干预措施: fast and exercise (Other)
exercise
Experimental
1 h ergometer cycling 50% VO2max
干预措施: exercise (Other)
结局指标
主要结局
Sirt1 activity
时间窗: 60 min
次要结局
- secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.(4 h)
研究者
研究点 (1)
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