The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Characterization of postoperative neurological impairment
研究概览
简要总结
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid much attention. This study is to determine the relationship between specific proteins in the blood and brain injury in patients less than 18-year-old undergoing heart surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •less than 18 years old
- •undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital
排除标准
- •undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent
- •patient in a moribund condition American Society of Anesthesiology (ASA 5)
- •patient with a hematological and/or oncological disease
- •Jehovah witnesses
- •patient on preoperative mechanical ventilation
研究组 & 干预措施
Cardiac Surgery Patients
Patients less than 18 years old who undergo cardiac surgical procedures on cardiopulmonary bypass.
干预措施: Collecting discarded blood samples (Other)
结局指标
主要结局
Characterization of postoperative neurological impairment
时间窗: 24 hours following surgery
Understand the correlation between measured proinflammatory cytokines and several proteins that are highly expressed in brain cells with postoperative neurological status.
次要结局
未报告次要终点
研究者
Koichi Yuki
Principal Investigator, MD
Boston Children's Hospital