Exploring the Neural Mechanisms of Imaginal Extinction Using fMRI and Psychophysiology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 试验地点
- 2
- 主要终点
- Blood oxygen level dependent contrast (BOLD-signal) during threat conditioning and imaginal extinction.
研究概览
简要总结
Imaginal exposure is a widely used and effective psychological treatment technique in which patients are exposed to fearful stimuli and situations using mental imagery. This study examines imaginal extinction, an experimental analogue of imaginal exposure that allows the study of this treatment technique under controlled circumstances. During imaginal extinction, conditioned fear is diminished through repeated exposure to mental imagery of the feared (conditioned) stimulus. The neural underpinnings of imaginal extinction is not known, and hence, this study examines neural activations during imaginal extinction using psychophysiology and brain imaging.
详细描述
In this study, participants undergo threat conditioning to two pictures (CS+, CS-) in order to acquire a conditioned threat response. After this, the conditioned threat response is diminished through imaginal extinction (i.e extinction to the mental imagery of CS+ and CS-). Functional magnetic resonance imaging (7T) is used to measure neural activations during threat conditioning and imaginal extinction. Skin conductance is used to measure arousal response. Subjective fear and mental imagery vividness ratings will also be collected. In this way, this study aims to characterize the neural underpinnings of imaginal extinction.
Note that this study employs participants fearful of spiders. This is because data collection is shared with a related study (ClinicalTrials.gov ID 2020-06930a).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing and able to provide informed consent and complete study procedures
- •Fear of spiders (due to data collection together with ID 2020-06930a)
排除标准
- •Current psychiatric disorder other than spider phobia. Current use of psychotropic medication. Current neurological conditions. MRI-contraindications (i.e metal implants in skull).
结局指标
主要结局
Blood oxygen level dependent contrast (BOLD-signal) during threat conditioning and imaginal extinction.
时间窗: Day 1
BOLD-signal is assessed using functional magnetic resonance imaging.
Physiological arousal response during threat conditioning and imaginal extinction.
时间窗: Day 1
Skin conductance responses are used as a measure of physiological arousal response (i.e. event-related rise in electrodermal activity to stimuli).
次要结局
- Task-specific mental imagery vividness during imaginal extinction(Day 1)
- Vividness of visual imagery Questionnaire (VVIQ)(One week after Day 1)
- Ratings of subjective fear experienced during threat conditioning and imaginal extinction.(Day 1)
- Spielberger State-Trait Anxiety Inventory (STAI-T)(One week after Day 1)