临床试验/NCT02139410

NCT02139410已完成不适用

Insulin Like Growth Factor 1 and Risks of Sarcopenia and Mortality in Patients With Cognitive Impairment

University of Roma La Sapienza2 个研究点分布在 1 个国家目标入组 589 人开始时间: 2008年6月最近更新: 2014年5月15日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 589
试验地点: 2
主要终点: IGF-1 reduction in patients with sarcopenia

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Insulin-like growth factor 1 (IGF)-1 is an important neuromyotrophic hormone. Disregulation of this hormone has been reported to influence the genesis of cognitive impairment and dementia in the elderly patients. We analyzed the possible link between IGF-1 and risk of Sarcopenia and Mortality in a cohort of elder patients with cognitive impairment.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 65 Years 至 90 Years（Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Diagnosis of cognitive impairment (MMSE < 24)
•Age > 65 ys

排除标准

•Diagnosis of pancreatic disorders
•Diagnosis of acromegaly
•Diagnosis of GH-related disorders
•Recent bone fractures or immobility before the enrollment (3 months)

结局指标

主要结局

IGF-1 reduction in patients with sarcopenia

时间窗: baseline, 24 months, 48 months

IGF-1 reduction could be linked to sarcopenia in patients with cognitive impairment

次要结局

IGF-1 reduction and mortality in patients with cognitive impairment(baseline, 24 months, 48 months)

研究者

发起方

University of Roma La Sapienza

申办方类型

Other

责任方

Principal Investigator

主要研究者

Vincenzo Gianturco

University of Roma La Sapienza

研究点 (2)

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