The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 2
- 主要终点
- Flow Mediated dilatation (FMD)
研究概览
简要总结
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic nerve activity
详细描述
Participants will have an acute exposure on 4 occasions1) e-cigarette with nicotine, 2) e-cigarette without nicotine, 3) nicotine inhaler, 4) sham control and undergo ECG recording for heart rate variability, endothelial function measurement using ultrasound ("FMD") and blood tests for oxidative stress markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Cardiac disease
- •Respiratory disease
- •Diabetes mellitus
结局指标
主要结局
Flow Mediated dilatation (FMD)
时间窗: 10 minutes after exposure
FMD is a measure of endothelial function
Heart rate variability (HRV)
时间窗: 10 minutes after exposure
HRV is a measure of cardiac sympathetic tone
次要结局
- Paraoxonase (PON)(~30 minutes after exposure)
研究者
Holly R Middlekauff
Professor of Medicine
University of California, Los Angeles