Clinical Evaluation Of The Effects Of Propolis Gargle On Wound Healing After Impacted Third Molar Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Edema
研究概览
简要总结
The goal of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate. The main question it aims to answer is:
Is propolis-containing gargle safe and effective alternative to chlorhexidine gluconate following impacted third molar surgery? Does propolis demonstrate comparable outcomes in pain control and mouth opening ?
详细描述
This prospective, randomized clinical study included 52 healthy patients (ASA I) who underwent impacted mandibular third molar surgery. Patients were randomly allocated into two groups: one group used 0.12% chlorhexidine gluconate gargle, while the other used a 3% propolis-containing gargle. Gargles were applied twice daily for one minute from postoperative day 2 to day 7. Pain was evaluated using the visual analog scale (VAS), while edema, maximum mouth opening, wound healing, and postoperative complications were assessed preoperatively and on postoperative days 2 and 7. Statistical significance was set at p < 0.05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of the impacted teeth were classified as Class II level B mesioangular position
- •Patients from a socioeconomic level who can actively use postoperative gargles
排除标准
- •Individuals with third molars exhibiting acute infection
- •pregnant women
研究组 & 干预措施
Propolis gargle
Patients were randomly allocated into two groups: one group used 0.12% chlorhexidine gluconate gargle, while the other used a 3% propolis-containing gargle. Gargles were applied twice daily for one minute from postoperative day 2 to day 7. Pain was evaluated using the visual analog scale (VAS), while edema, maximum mouth opening, wound healing, and postoperative complications were assessed preoperatively and on postoperative days 2 and 7.
干预措施: Third molar Surgery with propolis gargle (Procedure)
Chlorhexidine Gluconate gargle
Patients were randomly allocated into two groups: one group used 0.12% chlorhexidine gluconate gargle, while the other used a 3% propolis-containing gargle. Gargles were applied twice daily for one minute from postoperative day 2 to day 7. Pain was evaluated using the visual analog scale (VAS), while edema, maximum mouth opening, wound healing, and postoperative complications were assessed preoperatively and on postoperative days 2 and 7.
干预措施: Third molar surgery with chlorhexidine gluconate (Procedure)
结局指标
主要结局
Edema
时间窗: Before surgery to after surgery seventh day
Edema (assessed by measuring the distances between the tragus and lip corner, as well as the outer corner of the eye and mandibular corner, with measurements taken twice using a paper ruler and averaged), It was measured before surgery, after surgery second and seventh days.
Pain after surgery
时间窗: After surgery, post- op second and seventh day
Patient records were collected on the second and seventh days post-operation. The evaluated parameters included pain (measured using the VAS scale). Visual analog scale is used to measure pain intensity. It consists of a straight line usually 10 cm. 0: no pain, 10: worst pain imaginable. The patient marks the point that best represents their pain.
次要结局
- Maximum mouth opening(Before surgery to post surgery seventh day)
- Wound aperture(From surgery to seventh day after surgery)
研究者
Zeynep Bayramoglu
Associate Professor
Ataturk University