Exploring of Serum Biomarkers of Delirium After Cardiovascular Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 113
- 试验地点
- 1
- 主要终点
- Incidence of postoperative delirium
研究概览
简要总结
The incidence of postoperative delirium in patients after cardiovascular surgery is very high, which seriously affects the short-term and long-term prognosis of patients, but its mechanism is not clear. Recent studies have found that lactic acid participates in the process of sepsis by inducing histone lactatation in macrophages. histone H3 lysine 18 lactylation (H3K18la) is significantly associated with the severity of disease and inflammatory response. Inflammation plays an important role in postoperative delirium. We therefore hypothesized that macrophage H3K18la also plays a role in postoperative delirium. At the same time, the latest literature shows that the early markers of Alzheimer's disease (AD), such as Aβ, exosomes and phosphorylated tau, etc. [5], can also be detected in the serum of AD patients. Given the obvious correlation between Alzheimer's disease and postoperative delirium [6], we hypothesized that serum biomarkers of AD could also be used as serum biomarkers for postoperative delirium.
The objectives of this study were to investigate the correlation between H3K18 in serum monocytes and postoperative delirium and its severity in patients undergoing cardiovascular surgery. Meanwhile, we also detect the serum levels of biomarkers of AD, such as Aβ, tau and exosomes etc., in patients undergoing major cardiac surgery. We aim to find the serum biomarkers of delirium after major cardiac surgery, so as to provide a more convenient diagnostic basis for the prevention of postoperative delirium.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who receive cardiovascular surgery
- •Patients participated voluntarily and signed informed consent
排除标准
- •past medical history of neurological and psychiatric diseases; severe visual or hearing impairment;
研究组 & 干预措施
Delirium is determined by 3D-CAM score
No delirium is determined by 3D-CAM score
结局指标
主要结局
Incidence of postoperative delirium
时间窗: After surgery through to postoperative day 7
The incidence of postoperative delirium was determined according to the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) diagnostic algorithm. The algorithm consists of four clinical criteria: (1) acute onset and fluctuating course, (2) inattention, and either, (3) disorganized thinking, or(4) altered level of consciousness. To define a patient as having delirium, both the first and the second criteria have to be present, as well as either the third or the fourth criteria.
次要结局
- the level of H3K18 in serum monocytes of postoperative delirium and un-delirium patients(Perioperative data)
- the level of Aβ in serum of postoperative delirium and un-delirium patients(Perioperative data)
- the level of tau in serum of postoperative delirium and un-delirium patients(Perioperative data)
- the level of exosomes in serum of postoperative delirium and un-delirium patients(Perioperative data)
研究者
Hua Zheng
Associate Professor
Huazhong University of Science and Technology