The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease - The Link Between DISC1 and Cardiac Function in Patients With Schizophrenia

Left Ventricular Ejection Fraction (LVEF) measured by 2D Echocardiography

时间窗: Baseline

Left ventricular ejection fraction, LVEF will be reported in percentage (%) and obtained using Simpson's biplane method from 2D echocardiography.

Normalized Right Ventricular End-Diastolic Volume (RV EDV), echocardiographic parameter

时间窗: Baseline

RV EDV in mL will be normalized against body surface area (BSA) in m\^2 to report RV EDV normalized by BSA in mL/m\^2.

Fractional shortening measured by echocardiography

时间窗: Baseline

Fractional shortening will be reported as a percentage (%)

Global longitudinal strain (GLS), echocardiographic parameter

时间窗: Baseline

GLS(%) = (MLs - MLd)/MLd, where MLs is myocardial length at end-systole and MLd is the myocardial length at end-diastole. GLS will be reported in precentage (%)

Echocardiographic parameter TRpV, Tricuspid Regurgitation peak Velocity

时间窗: Baseline

TRpV is reported in m/s

Echocardiographic parameter, Indexed LV and RV stroke volumes

时间窗: Baseline

Indexed LV stroke volume and Indexed RV stroke volume will be reported in mL/m\^2 by by indexing the volumes (mL) to BSA (m\^2)

Left Ventricular Ejection Fraction (LVEF) measured by 3D Echocardiography

时间窗: Baseline

Left ventricular ejection fraction, LVEF will be reported in percentage (%) and obtained using 3D echocardiography

Left ventricular septal thickness, left ventricular posterior wall thickness and right ventricular wall thickness measured by echocardiography

时间窗: Baseline

Left ventricular septal thickness, left ventricular posterior wall thickness and right ventricular wall thickness will be reported in centimeters (cm)

Echocardiography parameter of ratio of E/e'

时间窗: Baseline

The E/e' ratio is derived from the E wave velocity to the e' velocity

Levels of NT-proBNP

时间窗: Baseline

Levels of NT-proBNP from blood samples will be reported in ng/L

DISC1 mRNA quantification

时间窗: Baseline

Measured from blood samples and reported as fold change

Levels of high sensitive-CRP

时间窗: Baseline

Levels of HS-CRP mg/L

Levels of CK-MB

时间窗: Baseline

Levels of CK-MB is reported in µg/L

Normalized Left Ventricular End-Diastolic Volume (LV EDV), echocardiographic parameter

时间窗: Baseline

LV EDV in milliliters (mL) will be normalized against body surface area (BSA) in m\^2 to report LV EDV normalized by BSA in mL/m\^2.

TAPSE echocardiographic parameter of right ventricular longitudinal systolic function

时间窗: baseline

TAPSE will be reported in millimeters (mm)

Echocardiographic parameters septal e' and lateral e' velocities

时间窗: Baseline

Septal e' and lateral e' velocities are reported as cm/s

Levels of Troponin I

时间窗: Baseline

Levels of Troponin I is reported in ng/L

Echocardiographic parameter MPI, Myocardial performance index

时间窗: Baseline

MPI is a unitless index derived from the sum of the isovolumic relaxation time (IVRT) and the isovolumic contraction time (IVCT) in milliseconds (ms) divided by the ejection time interval in (ms).

Echocardiographic parameter Mitral E/A ratio

时间窗: Baseline

Mitral E/A ratio is derived from the ratio of the E wave velocity to the A wave velocity

Levels of IGF1

时间窗: Baseline

Levels of IGF1 from blood samples will be reported in nmol/L

Levels of BDNF, brain derived neurotrophic factor

时间窗: Baseline

Levels of BDNF from blood samples will be reported in ng/mL

Levels of Transforming Growth Factor Beta

时间窗: Baseline

Levels of Transforming Growth Factor Beta from blood samples will be reported in ng/mL

Interleukin levels

时间窗: Baseline

Interleukin levels from blood sample will be reported as pg/mL

Levels of Troponin T

时间窗: Baseline

Levels of Troponin T is reported in ng/L

Normalized left Ventricular End-Systolic Volume (LV ESV), echocardiographic parameter

时间窗: Baseline

LV ESV in mL will be normalized against body surface area (BSA) in m\^2 to report LV ESV normalized by BSA in mL/m\^2.

Normalized Right Ventricular End-Systolic Volume (RV ESV), echocardiographic parameter

时间窗: Baseline

RV ESV in mL will be normalized against body surface area (BSA) in m\^2 to report RV ESV normalized by BSA in mL/m\^2.

Left ventricular mass measured by echocardiography

时间窗: Baseline

Left ventricular mass in grams (g) will be normalized against BSA in m\^2 and reported as g/m \^2

Echocardiography parameter of peak E velocity

时间窗: Baseline

peak E velocity is reported in cm/s

Echocardiography parameter of E wave deceleration time

时间窗: Baseline

E wave deceleration time is reported in milliseconds (ms)

Levels of Tumor Necrosis Factor alpha

时间窗: Baseline

Levels of Tumor Necrosis Factor alpha from blood samples will be reported in pg/mL

Echocardiographic parameter LAVI, left atrial volume indexed

时间窗: Baseline

LAVI is reported in mL/m\^2 and is the volume (mL) of the left atrium indexed against the BSA in m\^2.

Echocardiographic parameter, S wave velocity

时间窗: Baseline

S wave velocity is the peak systolic velocity of the tricuspid annulus and is reported in cm/s

Levels of ANP

时间窗: Baseline

Levels of ANP from blood samples will be reported in pg/mL

Levels of cardiac Myosin-Binding Protein C

时间窗: Baseline

Levels of cardiac Myosin-Binding Protein C from blood samples will be reported in ng/L