Endometrial Fluid Study in Natural Cycles: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Viscosity of endometrial fluid at D2 and D4 post ovulation of the normal cycle, respectively
研究概览
简要总结
This study is designed to collect information about the characteristics of endometrial fluid at day 2 and day 4 post-ovulation in normal fertile women.
详细描述
Implantation rates have stabilised around 35% in IVF and a current key rate limiting step is achieving successful implantation of the embryo. 1/3 of implantation failures are estimated to be caused by a problem with the receptivity of the endometrium. In recent years, several measurable parameters have been reported to assess endometrial receptivity. However, one parameter remains undescribed, the endometrial fluid viscosity.
It is generally believed that the viscosity change post ovulation is influenced by the luteal phase endocrine milieu, and it is possible that the viscosity of the endometrial fluid has an impact on implantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 35 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age: ≤ 35 years
- •Women eligible and qualified for egg donation at IVIRMA Bilbao
- •Proven fertile (having given birth to at least one spontaneously conceived normal child)
- •Signed written consent including sharing of anonymized data
排除标准
- •Contraindications for egg donation according to IVIRMA Bilbao guidelines
结局指标
主要结局
Viscosity of endometrial fluid at D2 and D4 post ovulation of the normal cycle, respectively
时间窗: 4 days
次要结局
- Plasma estradiol (E2) level(4 days)
- Plasma progesterone level(4 days)
- Endometrial thickness as measured by ultrasound(4 days)