Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers by Liquid BiopsY in Periphheral Blood: a Prospective Study (LIBRARY Study)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,608
- 试验地点
- 1
- 主要终点
- The sensitivity and specificity of the cfDNA methylation model in detection of liver, biliary tract and pancreatic cancers.
研究概览
简要总结
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA.
详细描述
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA. The study will enroll approximately 458 participants diagnosed with liver, biliary tract, and pancreatic cancers, 330 individuals with corresponding benign diseases and 820 healthy participants.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
The sensitivity and specificity of the cfDNA methylation model in detection of liver, biliary tract and pancreatic cancers.
时间窗: 24 months
次要结局
- The sensitivity and specificity of the combined model in detection of different subtypes of cancers.(24 months)
- The sensitivity and specificity of the combined model in detection of different stages of liver, biliary tract and pancreatic cancers.(24 months)