Persistence of Neutralizing Antibodies 6 and 12 Months After a Covid-19
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 170
- 主要终点
- anti-SARS-CoV-2 neutralizing antibody titers
研究概览
简要总结
Covid-19 is associated with the onset of anti-SARS-CoV-2 antibodies; in a majority of patients, neutralizing antibodies are detected. However, the long-term persistence of such protective antibodies is not known.
The investigators will explore patients with a proven Covid-19 (positive PCR) 6 and 12 months after the diagnosis to determine whether neutralizing antibodies are still detected.
The investigators will determine whether this persistance varies according to
- the severity of the Covid-19
- a treatment by steroids during the covid-19. This will help to anticipate whether a second wave of infection is possible in a non-naive population.
详细描述
Covid-19 is associated with the onset of anti-SARS-CoV-2 antibodies; in a majority of patients, neutralizing antibodies are detected. However, the long-term persistence of such protective antibodies is not known.
The investigators will explore adult patients with a proven Covid-19 (positive PCR) 6 and 12 months after the diagnosis to determine whether neutralizing antibodies are still detected.
The investigators will determine whether this persistance varies according to
- the severity of the Covid-19 (3 groups: no oxyegn therapy; oxygen therapy of less than 3L/min; oxygen therapy of 3L/min or more)
- a treatment by steroids during the covid-19. Immunocompromised patients will be excluded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •positive SARS-CoV-2
排除标准
- •age under 18
- •immunocompromised at the onset of Covid-19
结局指标
主要结局
anti-SARS-CoV-2 neutralizing antibody titers
时间窗: 1 day
Titer in plamsa of neutralizing anti-SARS-CoV-2 antibody
次要结局
未报告次要终点