NL-OMON42188已完成不适用
Cerebral Amyloid Angiopathy: Vascular Imaging and fluid markers of Amyloid deposition - CAVIA<br>Body fluid and imaging biomarkers for CAA
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 100 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Inclusion criteria for sporadic CAA group:
- •- Fulfilment of the modified Boston criteria for Cerebral Amyloid Angiopathy (CAA);Inclusion criteria for late-onset AD group:
- •- Fulfillment of the diagnostic criteria
- •- Available T2* MRI scan with information on presence or absence of CAA;Inclusion criteria for RUNDMC participants:
- •- Participants in the ongoing RUNDMC study (PI dr. FE de Leeuw) will be selected for the likelihood of the presence or absence of CAA, based on T2* MRI investigations that are already available.
排除标准
- •Exclusion criteria for MRI:
- •- Metal parts in the body (pacemaker, neurostimulator, clips, medication pumps, port-a-cath, hearing aids, cochlear implants, prostheses, piercings)
- •- Claustrofobia
- •- Difficulty with lying down for more than 30 minutes
- •- Pregnancy ;Exclusion criteria for Lumbar puncture:
- •- Allergy to local anesthetic agents
- •- Medical history of compression of spinal cord, spinal surgery, skin infection, developmental abnormalities in lower spine, blood coagulopathy, anticoagulant medication.
- •- Clinical (or previous MRI) evidence of structural (space occupying) cerebral abnormalities that are not compatible with the performance of an LP including malignancies, abscess or obstructive hydrocephalus.
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