Effect of Milk Proteins on Body Composition, Muscle Strength, Inflammation and Bone Health in Elderly Subjects

University of Oslo1 个研究点分布在 1 个国家目标入组 50 人2014年8月

适应症Healthy

概览

阶段: 不适用
干预措施: 未指定
疾病 / 适应症: Healthy
发起方: University of Oslo
入组人数: 50
试验地点: 1
主要终点: Change in muscle mass, strength and performance
状态: 已完成
最后更新: 10年前

概览研究者入排标准结局指标研究点相似试验

概览

简要总结

The aim of the present study is to investigate effects of milk on body composition and muscle strength, inflammation, appetite, DNA damage/repair and PBMC whole genome transcriptomics in elderly subjects.

注册库

clinicaltrials.gov

开始日期

2014年8月

结束日期

2015年9月

最后更新

10年前

研究类型

Interventional

研究设计

Parallel

性别

All

研究者

发起方

University of Oslo

责任方

Principal Investigator

主要研究者

Kirsten Holven

Professor

University of Oslo

入排标准

入选标准

•≥ 70 years of age
•reduced gait speed or
•reduced "five times sit to stand test" or
•reduced "timed step stair test " or
•reduced grip strength
•Stable body weight (last 3 months)
•Mini Nutritional Assessment (MNA®) score ≥ 17
•Mini-mental status (MMSE-NR) score: ≥ 24
•Willing to participate according to the protocol

排除标准

•Allergy/intolerance to milk/dairy products
•High intake of milk and yoghurt
•Physical active subjects
•Known diabetes type I or II, or HbA1c ≥ 6,5%
•Recent events of acute cardiovascular disease including stroke
•Rapidly evolving diseases (active malignancy) or history of cancer (malignant tumors) last 3 years.
•Severe inflammation-related diseases such as e.g. Crohn disease and arthritis
•Chronic obstructive pulmonary disease
•Increased blood pressure
•High intake of alcohol

结局指标

主要结局

Change in muscle mass, strength and performance

时间窗: Measured at baseline and after 12 weeks (end-of-study visit)

Change in muscle is mass measured by DXA. Muscle strength and performance are measured by several physical tests such as repeated chair stands, handgrip strength, step stair test and strength in legs and torso and gait speed and are considered as the clinical relevant outcomes.