Comparison of Ultrasound-Guided QLESP Block Versus Pericapsular Nerve Group Block Combined With Lateral Femoral Cutaneous Nerve Block on Postoperative Analgesia and Functional Recovery in Total Hip Arthroplasty: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- Postoperative 24-Hour Cumulative Opioid Consumption
研究概览
简要总结
Total hip arthroplasty (THA) is a common surgery to replace damaged hip joints, but many patients experience significant pain after surgery, which can delay recovery and increase the need for strong pain medications (opioids). Nerve blocks are a technique where anesthetic medication is injected near specific nerves to reduce pain. This study compares two different ultrasound-guided nerve block techniques for pain control after THA: the QLESP block (a newer technique that targets two areas with a single injection) and the PENG block combined with the LFCN block (a currently used technique that targets nerves around the hip joint and the outer thigh). Participants in this study will be randomly assigned (like a coin flip) to receive either the QLESP block or the PENG+LFCN block after surgery. The study aims to determine which nerve block provides better pain relief and reduces the need for opioid pain medications in the first 24 hours after surgery. Pain scores, recovery of leg movement, time to first walk, length of hospital stay, and any side effects will also be compared between the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 70 years
- •Scheduled for elective unilateral total hip arthroplasty via posterolateral approach
- •American Society of Anesthesiologists (ASA) physical status I-III
- •Body mass index (BMI) < 35 kg/m²
- •Ability to understand pain scoring and patient-controlled analgesia (PCA) use
- •Willing and able to provide written informed consent
排除标准
- •Allergy or hypersensitivity to local anesthetics (ropivacaine)
- •Long-term opioid use or chronic pain history requiring regular analgesic use
- •Active malignancy or infection at the puncture site
- •Severe psychiatric disorders or communication barriers
- •Severe cardiopulmonary disease
- •History of opioid abuse or substance dependence
- •Participation in another interventional clinical trial within 3 months prior to enrollment
- •Coagulation abnormalities
- •Pregnancy or breastfeeding
- •Any condition that, in the investigator's opinion, would compromise patient safety or data integrity
研究组 & 干预措施
QLESP Group
Participants receive ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL between the erector spinae and transverse process, and 15 mL between the quadratus lumborum and psoas major).
干预措施: QLESP Block (Procedure)
PENG+LFCN Group
Participants receive ultrasound-guided PENG block with 20 mL of 0.375% ropivacaine combined with LFCN block with 10 mL of 0.375% ropivacaine.
干预措施: PENG+LFCN Block (Procedure)
QLESP Group
Participants receive ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL between the erector spinae and transverse process, and 15 mL between the quadratus lumborum and psoas major).
干预措施: ropivacaine (Drug)
PENG+LFCN Group
Participants receive ultrasound-guided PENG block with 20 mL of 0.375% ropivacaine combined with LFCN block with 10 mL of 0.375% ropivacaine.
干预措施: ropivacaine (Drug)
结局指标
主要结局
Postoperative 24-Hour Cumulative Opioid Consumption
时间窗: At 24 hours after surgery
次要结局
- Postoperative VAS Pain Scores(At 6, 12, 24, 36, and 48 hours after surgery)
- Rescue Analgesia Requirement(Within 24 hours after surgery)
- Motor Block Assessment (Bromage Score)(At 6, 24, and 48 hours after surgery)
- Time to First Ambulation(From surgery end to first walk, up to 7 days)
- Length of Hospital Stay(From surgery date to discharge, up to 30 days)
- Incidence of Adverse Events(From surgery end to 48 hours after surgery)
研究者
Xi Wu
Principal Investigator
Huazhong University of Science and Technology