Word Retrieval in Aphasia
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Trained comprehension items
研究概览
简要总结
Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and/or comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.
详细描述
This study examines a retrieval practice-based naming treatment termed criterion learning. In criterion learning, each item's assigned criterion level dictates the number of times that item is correctly retrieved before it is dropped from further training within a session. Criterion learning optimally incorporates potent learning experiences, including spaced retrieval practice with emphasis on correct retrievals during training. The present study will provide critical observations for optimizing criterion learning for treating word processing deficits in people with aphasia. This study will recruit 20 community-dwelling individuals with aphasia, who will undergo comprehensive neuropsychological characterization. Subsequently, participants will engage in an experimental treatment designed to promote improvements in word processing deficits.
This study will examine transfer from two types of naming treatment to word comprehension performance. Each PWA will perform naming treatment in one session at different dosages with a test of comprehension performance administered approximately one week and one month following treatment. Main outcomes of interest will be degree of transfer of each type of naming treatment to comprehension performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •English as a native or primary language
- •Adults with stroke who are at least 6 months post-onset
- •Exhibit semantic comprehension deficit, defined as a minimum of 80 errors on word-picture verification pre-test
排除标准
- •History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease
- •History of a learning disability that significantly impacted language development, such as developmental language disorder
- •Insufficient stamina to participate in the protocol
研究组 & 干预措施
Criterion-learning practice
This is a single-arm study
干预措施: Criterion-learning practice (Behavioral)
结局指标
主要结局
Trained comprehension items
时间窗: approximately one-week and one-month following treatment
Word-picture verification task
次要结局
- Untrained comprehension items(pre-treatment, approximately one-week and one-month post-treatment)
- Trained naming items(a single session held during a single day, scheduled at the participant's convenience but typically held within two weeks following pre-treatment assessment)
- Trained comprehension items(pre-treatment)
研究者
Erica Middleton
Institute Scientist, Jefferson Moss Rehabilitation Research Institute
Albert Einstein Healthcare Network