The Effect of High-Intensity Interval Training on Cardiometabolic Risk Factors, Body Composition, and Plasma FABP4 Levels in Sedentary Obese Adults.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- Fatty acid-bling protein 4
研究概览
简要总结
It is aimed to investigate the responses of Fatty Acid Binding Protein 4 (FABP4), which has been discovered as a novel biomarker of obesity and metabolic diseases, to regular exercise training.
The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.
详细描述
Fatty acid binding proteins are intracellular proteins involved in the transport of fatty acids and are particularly associated with lipolytic activity. These proteins constitute a group of molecules that regulate intracellular lipid responses and are linked to metabolic and inflammatory pathways.
Studies have shown that FABP4 is associated with hypertension, insulin resistance, obesity, and stroke.
Inhibition of FABP4 synthesis has emerged as a promising strategy for the treatment of obesity-related conditions, particularly insulin resistance and diabetes, and it is emphasized that exercise models to suppress FABP4 should be further investigated.
The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.
Hypotheses:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 20 and 35 years,
- •BMI between 30 and 35 kg/m²,
- •Waist circumference of 90-100 cm for women, 105-110 cm for men,
- •Sedentary lifestyle (<600 MET-min/week),
- •Referred by a physician (with a statement confirming no contraindication to exercise)."
排除标准
- •BMI > 35,
- •Pregnancy,
- •Cardiovascular Diseases: Individuals with serious cardiovascular issues, such as uncontrolled hypertension, heart failure, coronary artery disease, or a heart attack within the last 6 months, which could pose a risk during exercise.
- •Respiratory Diseases: Individuals with chronic respiratory conditions, such as uncontrolled or severe asthma or COPD, who cannot tolerate exercise due to their condition.
- •Neurological Disorders: Individuals with neurological issues that limit exercise capacity, such as Parkinson's disease, stroke, or multiple sclerosis.
- •Musculoskeletal Issues: Individuals with chronic musculoskeletal problems, particularly knee or hip osteoarthritis, that may increase the risk of pain or injury during exercise.
- •Metabolic or Endocrine Disorders: Individuals with uncontrolled metabolic issues, such as diabetes or thyroid disorders, that could cause blood sugar or hormonal fluctuations during exercise.
- •Acute Infections or Illness: Individuals with acute infections, fever, or recently undergone surgical procedures.
- •Any health condition that may prevent participation in exercise."
结局指标
主要结局
Fatty acid-bling protein 4
时间窗: Baseline, week 6 and week 12
The Human FABP4 (Fatty Acid Binding Protein 4, Adipocyte) ELISA Kit/96T/Feiyuebio will be used to evaluate fatty acid-binding proteins in the biological samples collected from the participants.
Complete Blood Count
时间窗: Baseline, week 6 and week 12
used to evaluate overall health and detect a wide range of disorders, including anemia, infection, and many other diseases.
Hemoglobin A1c (HbA1c)
时间窗: Baseline, week 6 and week 12
used to measure the average blood glucose levels over the past 2 to 3 months; commonly used in the diagnosis and management of diabetes.
Hematocrit (HCT)
时间窗: Baseline, week 6 and week 12
sed to measure the proportion of red blood cells in the blood; helps evaluate conditions such as anemia, dehydration, and other blood disorders.
Low-Density Lipoprotein
时间窗: Baseline, week 6 and week 12
used to measure the level of "bad" cholesterol in the blood; high levels are associated with an increased risk of cardiovascular disease.
High-Density Lipoprotein
时间窗: Baseline, week 6 and week 12
Used to quantify the concentration of high-density lipoprotein (HDL) cholesterol in the bloodstream; elevated levels of HDL are inversely correlated with the risk of cardiovascular diseases, suggesting a protective effect on heart health.
Triglycerides
时间窗: Baseline, week 6 and week 12
used to measure the concentration of triglycerides (a type of fat) in the blood; elevated levels are associated with an increased risk of cardiovascular disease, metabolic syndrome, and other health conditions.
Fasting Blood Glucose (FBG)
时间窗: Baseline, week 6 and week 12
used to measure the concentration of glucose in the blood after an overnight fast; elevated levels may indicate impaired glucose metabolism or diabetes mellitus.
Total Cholesterol
时间窗: Baseline, week 6 and week 12
used to measure the overall concentration of cholesterol in the blood, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL); elevated levels are associated with an increased risk of cardiovascular diseases.
次要结局
- Physical Activity Level Assessment(Baseline, week 6 and week 12)
- Physical activity level(Baseline, week 6 and week 12)
- Assessment of Aerobic Capacity and Exercise Intensity - used to measure an individual's maximal oxygen uptake (VO2max) and determine the intensity of exercise(Baseline, week 6 and week 12)
- Anthropometric Measurements(Baseline, week 6 and week 12)
- Antropometric Measurement(Baseline, week 6 and week 12)