The comparative effects of injecting Intra- Articular Platelet-Rich Plasma and Hypertonic Dextrose Prolotherapy in Osteoarthritis Knee- A Randomized Control Trial

King Georges Medical University0 个研究点目标入组 85 人开始时间: 待定最近更新: 2024年1月22日

试验速览

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•(1) Age =50 to <75 year old.
•(2) Diagnosis of primary knee OA based on clinical criteria as defined by the American college of Rheumatology Association.
•3) Moderate to severe knee pain for at least 3 months.
•4) Failure to achieve pain and swelling reduction after 3 months of usual care, such as weight reduction, exercise, physical therapy and pharmacological treatment.
•5) Radiographic evidence of knee OA (KL grade 1, grade 2, grade3).
•6) BMI <30kg/m2
•7) Patient willing to participate in the study.

•1) History with uncontrolled Diabetes Mellitus.
•2) OA knee: KL grade 4.
•3) Patients on anticoagulant therapy.
•4) Prior intra-articular knee injections within 3 months, other than platelet- rich plasma therapy (PRP therapy) and hypertonic dextrose prolotherapy
•5) Inflammatory or post-infectious knee arthritis, such as clinically diagnosed rheumatoid arthritis, gouty arthritis, psoriatic arthritis and septic arthritis.
•6) A history of previous knee pathology.
•7) A history of any recent trauma to the hip joint or in the pelvic region interfering with ADL or causing any deformity
•8) Patients with Hb < 10 gm/dl and platelet values <150,000/ml
•9) Paralysis of lower extremities.
•10) Significant effusion as defined by a ballotable patella.
•11) Any disease other than osteoarthritis Knee

发起方

King Georges Medical University