NCT02884063已完成不适用
Utilizing Free DNA in Embryo Culture Media for Preimplantation Genetic Screening
Al Baraka Fertility Hospital0 个研究点目标入组 100 人开始时间: 2015年5月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 主要终点
- DNA isolation
研究概览
简要总结
In the way for developing and optimizing protocol to be used as non- invasive methodology used as routine testing for PGS.
This protocol is to be adapted to replace the using of life embryo cells for genetic testing and aneuploidy study as well as for any type of genetic testing including single gene disorder or HLA typing or study.
详细描述
Compare 100 embryos studied using NGS for chromosomal aneuploidies, and compare the results came from free media DNA with this results.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all abnormal/aneuploidy embryos rejected for embryo transfer.
排除标准
- •all embryos had unsuccessful diagnosis with blastomere biopsy.
结局指标
主要结局
DNA isolation
时间窗: 2 years
reading amplified DNA using NGS
次要结局
- NGS evaluation(2 years)
- Comparison with cell reading using NGS(2 years)
研究者
Ahmad Mustafa Mohamed Metwalley
IVF laboratory manager
Al Baraka Fertility Hospital
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