Time Course of Endometrium's Gene Expression and DNA Methylation Profiles Using Endometrial Tissue and Blood Samples
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- miRNA expression profiles
研究概览
简要总结
This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Regular menstrual cycle of 28-32 days.
- •Between 25-38 years old.
- •BMI between 18 to
- •Endogenous progesterone (P4) level of < 1 ng/mL prior to exogenous progesterone administration
排除标准
- •Suspected intrauterine abnormality.
- •Women who are breastfeeding
- •Have a history of pelvic inflammatory disease, reproductive tract-related diseases, sexually transmitted diseases, systemic diseases or endocrine diseases.
- •History of major illness.
- •Use of hormonal contraceptives or intrauterine devices in the past 3 months.
研究组 & 干预措施
P+3
Women who get their blood drawn and endometrial tissue biopsy taken at 3 days after progesterone administration starts.
干预措施: Small RNA sequencing (Genetic)
P+4
Women who get their blood drawn and endometrial tissue biopsy taken at 4 days after progesterone administration starts.
干预措施: Small RNA sequencing (Genetic)
P+5
Women who get their blood drawn and endometrial tissue biopsy taken at 5 days after progesterone administration starts.
干预措施: Small RNA sequencing (Genetic)
P+6
Women who get their blood drawn and endometrial tissue biopsy taken at 6 days after progesterone administration starts.
干预措施: Small RNA sequencing (Genetic)
P+7
Women who get their blood drawn and endometrial tissue biopsy taken at 7 days after progesterone administration starts.
干预措施: Small RNA sequencing (Genetic)
结局指标
主要结局
miRNA expression profiles
时间窗: 1 month
The samples collected would undergo small RNA sequencing in order to investigate the miRNA expression profiles of the patients and differences in expression profiles between the different intervention groups.
次要结局
未报告次要终点