Pruritus After Intrathecal Morphine in Cesarean Section: Incidence, Severity and Its Relation to Serum Serotonin Level
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Pruritus
研究概览
简要总结
Pruritus is the commonest side effect of intrathecal morphine especially in parturient, but the exact mechanism of pruritus is not clear. Many mechanisms have been suggested. Among these mechanisms is the activation of the 5-HT3 receptors by the intrathecally injected morphine.
详细描述
Forty parturients underwent elective cesarean section under spinal anesthesia were divided into two groups of 20 each in this prospective randomized study. Group I received 100 µg of intrathecal morphine (ITM) mixed with 12 mg of 0.5% heavy bupivacaine (M100) while group II received 200 µg of ITM mixed with 12 mg of 0.5% heavy bupivacaine (M200). Two blood samples were taken from each patient for serotonin estimation, preoperatively and 4 hrs later. Postoperatively all patients were assessed for pruritus (incidence & severity), visual analog scale (VAS), first request of analgesia, and total analgesic dose required within 24 hrs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA I - II term pregnant patients scheduled for elective cesarean section
排除标准
- •patients with a known allergy to the study drugs
- •significant cardiac, respiratory, renal, neurological, or hepatic disease; -coagulation disorders
- •BMI > 30 kg/m2
- •any itchy skin diseases.
研究组 & 干预措施
Group I
intrathecal injection of 100 μg morphine
干预措施: Morphine 100 μg (Drug)
Group II
iIntrathecal injection of 200 μg morphine
干预措施: Morphine 200 μg (Drug)
结局指标
主要结局
Pruritus
时间窗: 24 hours postoperative
severity
次要结局
- serotonin(4 hours postoperative)
研究者
Mohamed galal aly
Assistant professor
Assiut University