CA-125 and Severity of Pre-Eclampsia

Although the source of CA-125 during pregnancy is the fetal chorion, amniotic fluid, and maternal decidua, the perinatal dynamics of maternal serum CA-125 requires clarification. Clinical studies of CA-125 levels and its function in hypertensive pregnant patients are limited and offered contradictory results (Cebesoy et al., 2009).

And so we investigate CA-125 in normal pregnancy and in pre-eclampsia, comparing mild and sever pre-eclampsia to determine relationship of CA-125 and severity of the disease.

Patients will be divided in three groups:

• Control: 40 normal healthy pregnant women attending the ER in labor.

• Mild pre-eclampsia: 40 patients fulfilling the following criteria.

• Blood pressure: systolic blood pressure >140 and <160 , Diastolic blood pressure >90 and <110

• Proteinuria: 300 mg (+) assessed by urine urignost 3A® (urine strips from DIALAB).

• No symptoms of severity as headache.

• Normal investigations for different organ function (as liver and kidney function).

• Severe pre-eclampsia :40 patients fulfilling anyone or more of the following criteria (The American College of Obstetricians and Gynecologists, 2010)(ACOG):