Acute Exercise and Cognitive Function: Examining the Role of Weight Status and Exercise-Induced Myokines
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Circulating Cathepsin B (CTSB) Myokine
研究概览
简要总结
The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims:
Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity.
Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity.
Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.
详细描述
18 adults with healthy weight (BMI 18.5-25.0kg/m2) and 18 adults with obesity (BMI 30.0kg/m2) will be asked to complete a counter-balanced crossover trial. After initial baseline testing, participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order. A cognitive testing battery accompanied by an electroencephalogram (EEG) will be administered following each session. Blood samples will be collected prior to, during, and following each throughout each testing condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between ages 18 and 35
- •No prior diagnosis of neurological disorders (e.g., autism spectrum disorder)
- •No prior diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
- •No physical disability that would preclude the participant from completing a VO2max test
- •Corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
- •Not pregnant
- •BMI between 18.5 and 25.0 kg/m2, or BMI greater than 30.0 kg/m2
- •Readiness for exercise (determined through PAR-Q)
排除标准
- •<18 years and >35 years
- •Diagnosis of neurological disorders (e.g., autism spectrum disorder)
- •Diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
- •Physical disability that would preclude the participant from completing a VO2max test
- •Lack of corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
- •Pregnancy
- •BMI less than 18.5 kg/m2 or BMI greater than 25.0 but less than 30.0 kg/m2
结局指标
主要结局
Circulating Cathepsin B (CTSB) Myokine
时间窗: 3 hours
Changes in peripheral myokine concentration
Attentional Processing Speed
时间窗: 3 hours
Changes in P3 event related potential latency (ms) using a computerized flanker task
Attentional Inhibition Accuracy
时间窗: 3 hours
Behavioral performance measured as accuracy (%) during Flanker task
Relational Memory
时间窗: 3 hours
Accuracy during a spatial reconstruction task
Attentional Resource Allocation
时间窗: 3 hours
Changes in P3 event related potential amplitude (microvolts) using a computerized flanker task
Attentional Inhibition Reaction Time
时间窗: 3 hours
Behavioral performance measured as response time (ms) during Flanker task
次要结局
- Brain derived neurotrophic factor (BDNF)(3 hours)