NCT03164590已完成4 期
Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- severity of pain at rest and on coughing
研究概览
简要总结
This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA I-II patients
- •age range (18-60) years,
- •weight (50- 90) kg
排除标准
- •allergy to study drugs
- •significant cardiac disease
- •respiratory disease
- •renal disease
- •hepatic disease
研究组 & 干预措施
ketamine
Active Comparator
干预措施: Ketamine (Drug)
dexmedetomidine
Active Comparator
干预措施: dexmedetomidine (Drug)
bupivacaine
Placebo Comparator
干预措施: Ketamine (Drug)
bupivacaine
Placebo Comparator
干预措施: dexmedetomidine (Drug)
bupivacaine
Placebo Comparator
干预措施: bupivacaine (Drug)
结局指标
主要结局
severity of pain at rest and on coughing
时间窗: 24 hours
severity of pain at rest and on coughing will be assessed using a 10-cm Visual Analog Scale (0 = no pain and 10 = worst imaginable pain)
次要结局
- sedation(24 hours)
研究者
Fatma Adel El sherif,MD
lecturer of anesthesia ,ICU and pain releif
Assiut University
研究点 (1)
Loading locations...
相似试验
已完成
3 期
Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical StressAbdominal CancerNCT02927379Assiut University90
已完成
1 期
Subcutaneous Wound Infiltration of Ketamine or Bupivacaine Pain Perception After Cesarean SectionPostoperative PainNCT02515422Huseyin Aksoy120
已完成
2 期
Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP BlockPostoperative AnalgesiaLower Abdominal CancerNCT03060070Assiut University90
已完成
3 期
Ultrasound-guided Regional Anesthesia vs Local Infiltration Anesthesia With Dexmedetomidine and RopivacainePain, PostoperativeAnesthesia, LocalGonarthrosisNCT04697537Medical University of Graz50
已完成
2 期
Effect of a Topical Ketamine on Acute and Chronic Pain, Dose FindingBreast CancerNCT03165149Assiut University90