Effects of Lepidium Meyenii (Maca) Extract Supplementation on Immune Function, Inflammatory Responses, Oxidative Stress After Strenuous Endurance Exercise
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Concentration of GPx
研究概览
简要总结
The aim of this study is to investigate Lepidium meyenii (Maca) extract supplementation on exercise-induced responses of the biochemical, and physiological parameters.
详细描述
Thirty healthy male participants were divided into Maca group (2.25 g of Maca extract, twice per day for 12 weeks) and placebo group (n = 15). All participants conducted a graded exercise test on treadmill to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 70% VO2max was conducted for an exhaustive endurance exercise test by treadmill for 1 hours, followed by 90% VO2max until exhaustion.The time to exhaustion, peak oxygen consumption, maximal heart rate and average heart rate will be recorded during the exercise period. Venous blood samples will be drawn before, immediately after, 2-hour after, 4-hour after, and 24-hour after the exhaustive endurance exercise test. Data was analyzed by Two-way mixed design ANOVA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
A double-blind, matched-pair study design
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The volunteers included have conditions as stated below :
- •male adult whose no history of cardiovascular, liver, kidney and diabetes disease
- •no acute sport injury
- •did not participated in any clinical trials or research in the last 3 months before our experiment
- •no supplements were taken during the experimental period
- •were requested to maintain their regular daily life style and avoid alcohol intake
排除标准
- •The volunteers were excluded if they have the situation stated below:
- •history of cardiovascular, liver, kidney and diabetes disease
- •acute sport injury
- •participated in any clinical trials or experimental research in the last 3 months before our experiment
- •taking supplement during the experimental period
- •did not maintain their regular eating habit or drink alcohol
结局指标
主要结局
Concentration of GPx
时间窗: 24-hour after exercise
Concentration of CK
时间窗: 24-hour after exercise
Concentration of IL-6
时间窗: 24-hour after exercise
Concentration of leukocyte
时间窗: 24-hour after exercise
Concentration of neutrophil
时间窗: 24-hour after exercise
Concentration of IFN-γ
时间窗: 24-hour after exercise
Concentration of CD4+
时间窗: 24-hour after exercise
Concentration of lymphocyte
时间窗: 24-hour after exercise
Concentration of GSSG
时间窗: 24-hour after exercise
Concentration of IL-4
时间窗: 24-hour after exercise
Concentration of IL-10
时间窗: 24-hour after exercise
Concentration of testosterone
时间窗: 24-hour after exercise
Concentration of LH
时间窗: 24-hour after exercise
Concentration of NO
时间窗: 24-hour after exercise
Concentration of GOT
时间窗: 24-hour after exercise
Concentration of GPT
时间窗: 24-hour after exercise
Concentration of BUN
时间窗: 24-hour after exercise
Concentration of GSH
时间窗: 24-hour after exercise
Concentration of CD8+
时间窗: 24-hour after exercise
Concentration of CD19+
时间窗: 24-hour after exercise
Concentration of CK-MB
时间窗: immediately after exercise
Concentration of IL-1β
时间窗: 24-hour after exercise
Concentration of CD56+
时间窗: 24-hour after exercise
IConcentration of GSSG
时间窗: before exercise
Concentration of TNF-α
时间窗: 24-hour after exercise
Concentration of IL-2
时间窗: 24-hour after exercise
Concentration of SOD
时间窗: 24-hour after exercise
Concentration of catalase
时间窗: 24-hour after exercise
Concentration of LDH
时间窗: 24-hour after exercise
Concentration of creatinine
时间窗: 24-hour after exercise
Concentration of IL-8
时间窗: 24-hour after exercise
Concentration of TBARS
时间窗: 24-hour after exercise
Concentration of PC
时间窗: 24-hour after exercise
Concentration of cTnI
时间窗: 24-hour after exercise
Concentration of NT proBNP
时间窗: 24-hour after exercise
Concentration of FSH
时间窗: 24-hour after exercise
次要结局
未报告次要终点