Measurement of Ocular Rigidity, Outflow Facility and Ocular Blood Flow in Glaucomatous and Normal Eyes
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Ocular rigidity coefficient
研究概览
简要总结
Ocular rigidity characterizes the relationship between pressure and volume changes in the human eye and is expressed as a macroscopic coefficient. Outflow facility is a measure of the resistance of the conventional outflow pathway and represents a parameter that is of interest in glaucoma.
Difficulties in the measurement of ocular rigidity in the living human eye have limited our knowledge on this parameter. However, ocular biomechanics have been implicated in the pathogenesis of this disease. The aim of this study is to characterize the pressure volume relation and quantify ocular rigidity and outflow facility in glaucomatous and normal eyes. For this purpose, the investigators have recently developed a manometric method for the measurement of ocular rigidity and outflow facility.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with primary open or pseudoexfoliation glaucoma that are undergoing cataract surgery
- •Patients undergoing cataract surgery without evidence of other ocular disease.
排除标准
- •Evidence of any ocular disease, other than specified in the inclusion criteria
- •Previous ophthalmic surgery or trauma
- •Significant visual field defect (MD<-12dB) or an increased cup to disc ratio (>0.9).
结局指标
主要结局
Ocular rigidity coefficient
时间窗: 2 minutes measurement of ocular rigidity
Outflow facility coefficient
时间窗: 3-4 minutes measurement of outflow facility
次要结局
- Pulsatile ocular blood flow(6 minutes)
- Ocular pulse amplitude(6 minutes)
研究者
Anna Dastiridou
MD, PhD
Larissa University Hospital