The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- the presence of Treg cells and pinopodes in the endometrium
研究概览
简要总结
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. It has been demonstrated that regulatory T cells expand during pregnancy. hCG was found to be secreted by the embryo immediately after fertilization and has chemoattractant properties to Treg cells.
详细描述
Aim of the work:
To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics.
Background:
It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy.
Rational:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Male factor infertility
- •Ovulatory factor infertility
- •Unexplained infertility
- •Female age less than 39
排除标准
- •Azoospermia
- •Tubal factor infertility
- •Pelvic endometriosis
研究组 & 干预措施
intrauterine hCG
intrauterine injection of 100 hCG followed by endometrial biopsy
干预措施: human chorionic gonadotrophin (Drug)
结局指标
主要结局
the presence of Treg cells and pinopodes in the endometrium
时间窗: 4 weeks
次要结局
- pregnancy rate(4 weeks)
研究者
Ragaa Mansour
Director, the Egyptian IVF-ET Center
The Egyptian IVF-ET Center