Objective Sleep Characteristics and Response to Neoadjuvant Immunotherapy in Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
研究概览
简要总结
This prospective observational study will enroll 120 patients with locally advanced gastric or gastroesophageal junction adenocarcinoma who are scheduled to receive neoadjuvant immunotherapy followed by radical surgery. Non-invasive objective sleep monitoring will be performed during the neoadjuvant treatment period to assess sleep characteristics, including sleep duration, sleep efficiency, device-estimated deep sleep proportion, nocturnal awakenings, sleep regularity, heart rate, and heart rate variability. The primary objective is to evaluate the association between objective sleep characteristics and major pathological response (MPR) after neoadjuvant immunotherapy. This study will not alter standard treatment decisions, surgical procedures, or perioperative management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than 18 years, regardless of sex.
- •Histologically confirmed gastric adenocarcinoma or gastroesophageal junction adenocarcinoma.
- •Locally advanced, resectable disease as assessed by imaging or a multidisciplinary team, based on the 8th edition of the AJCC staging system, typically cT3-4a, any N, or any T with N-positive disease, corresponding to stage II-III disease, without distant metastasis.
- •Scheduled to receive neoadjuvant therapy followed by radical surgery.
- •Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-
- •No prior systemic anticancer therapy for the current tumor at study baseline.
- •Willing to participate in the study and able to provide written informed consent.
排除标准
- •Presence of distant metastasis, peritoneal metastasis, or disease considered no longer suitable for curative-intent treatment.
- •Prior neoadjuvant chemotherapy, immunotherapy, radiotherapy, or other systemic anticancer therapy for the current tumor.
- •Severe cognitive impairment, acute psychiatric disorder, or any other condition that prevents the participant from completing study procedures.
- •Current treatment with antidepressants, anxiolytics, sedative-hypnotics, or other psychotropic medications, with any of the following occurring within 4 weeks before enrollment:
- •Increase or decrease in the dose of the relevant medication by 25% or more from the previous maintenance dose;
- •Initiation, discontinuation, or replacement of antidepressants, anxiolytics, sedative-hypnotics, or other psychotropic medications;
- •Adjustment of treatment due to worsening anxiety, depression, insomnia, or other psychiatric or psychological symptoms;
- •Any medication change or psychological condition judged by the investigator to potentially affect sleep monitoring results or study compliance.
- •Any other condition that, in the opinion of the investigator, makes the participant unsuitable for this study.
研究者
Ting Liu
PhD/MD
West China Hospital