EUCTR2007-004979-19-DE进行中（未招募）1 期
In-vivo assessment of nicotinic acetylcholine receptor binding in neurodegenerative diseases using the radioligand 2-[18F]FA-85380 and positron emission tomography (PET) - Nicotinic-PET in neurodegenerative diseases
niversity of Leipzig0 个研究点目标入组 300 人开始时间: 2009年8月3日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •(1) Patients: neurodegenerative diseases (dementia, movement disorders, white matter diseases) according to the disease specific diagnostic criteria (DSM V, ICD-10) including also neuropsychological tests (CDR, NINCDS-ADRDA, MMSE, DemTect, UPDRS, EDSS)
- •(2) Patients: must be compliant and willing to give informed consent
- •(3) Patients: should not have cholinergic drugs prior scanning (more than 2 weeks cessation)
- •(4) Control subjects: no history of or current neuropsychiatric disease or drug treatment/abuse, no intracerebral structural defects
- •(5) Age: 18 - 90 years
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •(1) Patients with drug-/ or alcohol abuse
- •(2) Severe phobia/reduced compliance that make PET investigation impossible or other diseases that do not allow PET or MRI scanning
- •(3) Pregnancy
- •(4) Malignant brain tumor
- •(5) History of choline esterase inhibitors (CHEI)
- •(6) Smoking
- •(7) For healthy controls: history of neurological or psychiatric disorders, pathological MRI scan
- •(8) Lack of compliance
- •(9) Previous radiation exposure in profession or in studies
- •(10) Abnormal blood/urine testing
研究者
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