NL-OMON56339尚未招募不适用
Assessment of myocardial function, endothelial function and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM - FUSION-HCM
Amsterdam UMC0 个研究点目标入组 100 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •MYBPC3 mutation carrier
- •MYH7 mutation carrier
- •Genotype-negative first degree relative of a MYBPC3 or MYH7 mutation carrier
排除标准
- •>=70 years old
- •Insulin-dependent diabetes mellitus
- •Claustrophobia
- •Pacemaker/ICD
- •Renal insufficiency <30 GFR
- •Hypertension (systolic >140mmHg or diastolic >90mmHg)
- •For the genotype negative group, no phenotype group, and mild phenotype group:
- •the use of blood pressure medication (diuretics, beta-blockers, ACE-inhibitors,
- •angiotensin II receptor blockers, calcium channel blockers, alpha blockers)
- •For the HCM phenotype group: when it is unsafe to withhold from blood pressure
- •medication (as specified above) for two days, as assessed by their own
- •cardiologist
- •Left ventricular outflow tract gradient > 50mmHg
- •Aortic valve disease
- •Left bundle branch block
- •(History of) Obstructive coronary artery disease
- •Chronic atrial fibrillation
- •Hormone replacement therapy
- •Second or third-degree AV-block, sick-sinussyndrome, prolonged QT-interval
- •Asthma and other obstructive pulmonary diseases
- •Previous adverse reaction to adenosine or dotarem
研究者
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