The Effect of Propofol on Tissue Doppler Imaging of Mitral Valve Annular Velocity During Remifentanil-based Cardiac Anesthesia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change of systolic mitral valve annular velocity (S')
研究概览
简要总结
The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging
详细描述
The purpose of this study is to evaluate the effects of different concentration of propofol on patients who are undergoing cardiac surgery. The patients will receive infusion remifentanil 0.5mcg/kg/min with different target-site propofol concentration namely 1.0ng/ml, 2.0ng/ml and 3.0ng/ml. Tissue Doppler Imaging by transesophageal echocardiography will be done to assess the changes in cardiac function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing cardiac surgery
排除标准
- •low ejection fraction < 50% on transthoracic echocardiography atrial fibrillation pacemaker pericardial and infiltrative myocardial disease mitral annular calcification, surgical rings, prosthetic mitral valve lateral left ventricular wall motion abnormality oesophageal abnormality history of extensive radiation to the mediastinum upper gastrointestinal bleeding
研究组 & 干预措施
Propofol 1.0mcg
Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 1.0mcg/ml using target controlled infusion.
干预措施: Propofol 1.0mcg (Drug)
Propofol 2.0mcg
Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 2.0mcg/ml using target controlled infusion.
干预措施: Propofol 2.0mcg (Drug)
Propofol 3.0mcg
Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 3.0mcg/ml using target controlled infusion.
干预措施: Propofol 3.0mcg (Drug)
结局指标
主要结局
Change of systolic mitral valve annular velocity (S')
时间窗: 10 min after achieving 3 different propofol concentrations
To examine the effect of Propofol at different effect-site concentration ( 1.0 ng/ml, 2.0 ng/ml and 3.0 ng/ml) on S' (systolic mitral valve annular velocity) during remifentanil-based anesthesia.
次要结局
- phenylephrine infusion rate(10 min after achieving 3 different propofol concentrations)
- Early diastolic mitral valve annular velocity (e')(10 min after achieving 3 different propofol concentrations)
- late diastolic (atrial contractile) mitral valve annular velocity (a')(10 min after achieving 3 different propofol concentrations)
- ejection fraction(10 min after achieving 3 different propofol concentrations)
研究者
Tae-Yop Kim, MD PhD
Professor
Konkuk University Medical Center