Comparative Analysis of Serum Lipid Profiles in Patients With and Without Gallstones: A Prospective Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- serum HDL levels
研究概览
简要总结
Gallbladder disease is one of the most common diseases of the gastrointestinal tract. Various studies have shown an association between gallstones and an alteration in the serum lipids. The objective of this study will be to compare serum lipid profile of gallstone patients with the controls.
详细描述
This prospective cross-sectional study will be conducted in the Surgical Department of the Services Institute of Medical Sciences. A total of 50 patients will beincluded in the study after screening through the inclusion criteria. A control group of 50 inpatients with no personal or family history of gallstones will be also recruited for comparison. Results will be expressed as mean with standard deviation. Students t- test will be used to compare the data between the patients and the control groups (p<0.05 will be considered statistically significant). SPSS software, version 20 will be used for statistical analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients with the gall stone disease
- •Age from 20 to 70 years
- •Gallstones were diagnosed through the ultrasound
排除标准
- •Patients with acalculous gallbladder disease on ultrasound,
- •Patients with terminal ileal resection,
- •Patients with hemolytic diseases (hereditary spherocytosis, sickle cell anemia on history and CBC film),
- •Patients with liver cirrhosis (on abdominal ultrasound) and
- •Patients on antihyperlipidemic drugs
结局指标
主要结局
serum HDL levels
时间窗: 1 week
serum HDL levels of patients and contoled will be compared with student t-test (p\<0.05 was considered statistically significant)
serum triglyceride levels
时间窗: 1 week
serum triglyceride levels of gallstone patients and control group will be compared via student t-test (p\<0.05 was considered statistically significant)
serum cholesterol levels
时间窗: 1 week
serum cholesterol levels of patients and case group will be compared with Students t- test was (p\<0.05 will be considered statistically significant)
serum LDL leves
时间窗: 1 week
serum LDL leves of patients and control will be compared through student t-test (p\<0.05 was considered statistically significant)
次要结局
未报告次要终点
研究者
Dr. SamiUllah
Principle investigator
Services Hospital, Lahore