Different Effects of Sevoflurane, Propofol and Combine of Sevoflurane and Propofol Maintained Anesthesia on Peripheral Blood Lymphocytes During Off-pump Coronary Artery Bypass Graft Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Lymphocyte Count
研究概览
简要总结
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •male adults
- •aged 18-80 yr
- •undergoing elective OPCAB surgery containing left anterior descending artery bypass
排除标准
- •a previous unusual response to any of the experimental anesthetics
- •severe cardiac dysrhythmias or ejection fraction below 30%
- •hemodynamic instability
- •previous surgical coronary artery repair
- •anemia, abnormal leukocytes or coagulopathy
- •severe hypertension
- •severe hepatic (albumin<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions
- •concomitant surgical procedures and psychiatric disorders
- •Insulin-dependent diabetics
研究组 & 干预措施
Sevoflurane
干预措施: Sevoflurane (Drug)
Propofol
干预措施: Propofol (Drug)
Combine of sevoflurane and propofol
干预措施: combine of sevoflurane and propofol (Drug)
结局指标
主要结局
Lymphocyte Count
时间窗: 1 day after surgery
Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.
次要结局
- Intensive Care Unit Staying Days(participants will stay in intensive care unit after surgery, an expected average of 2 days)