NCT01679444已完成不适用
Magnetic Resonance Spectroscopy Probe Study of Alcohol Use
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Utilizing Magnetic Resonance Spectroscopy at 3 Tesla, investigate the neurobiological underpinnings of alcohol craving
研究概览
简要总结
This protocol will investigate the neurobiological underpinnings of alcohol craving in recently detoxified alcoholic drinkers utilizing novel functional brain imaging. This clinical magnetic resonance spectroscopy (MRS) study will investigate whether glutamate and other brain metabolites correlate to measures of alcohol craving severity
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(Minimal or No Alcohol Group)
- •Male or female age 21-70
- •Consume less alcohol then what is described in this protocol as a "higher dose drinker", or consume no alcohol at all.
- •Able to complete a 60 min. MRS brain scan.
排除标准
- •Inability to speak English
- •Inability or unwillingness to provide written informed consent
- •Diagnosis of active substance dependence other than nicotine (e.g. alcohol, cannabis, caffeine, prescription use of barbiturates, benzodiazepines, opiates, or stimulants) this will be determined using a PRISM (Psychiatric Research Interview for Substance and Mental Disorders) interview.
- •Any unstable active medical or additional psychiatric condition as determined by the investigator
- •Active suicidal ideation as determined by the PHQ-9 question 9 indicating response #2 or higher (several days; more than half the days; or nearly every day).
- •History of encephalopathy, hepatic failure, or HIV seropositivity
- •History of claustrophobia
- •History of major head trauma with loss of consciousness >5 minutes or skull fracture
- •History of previous neurological event (e.g. epilepsy, stroke, transient ischemic attack)
- •Implanted metal objects (e.g. pacemakers; aneurysm clips; metal prostheses, joints, rods, or plates)
- •Contraindication to MRI scanning
- •Pregnancy or breast-feeding
结局指标
主要结局
Utilizing Magnetic Resonance Spectroscopy at 3 Tesla, investigate the neurobiological underpinnings of alcohol craving
assessing baseline perturbations in anterior cingulate and ventral striatal metabolites (NAA levels, glutamate levels, glutamine levels)
次要结局
- Evaluate the relationship between these metabolites, each reported as a Cerebrospinal Fluid-corrected absolute concentration, and severity of alcohol cravings
研究者
研究点 (2)
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