Morning / Afternoon Variation in Myocardial Ischemia Tolerance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- ischemia reperfusion injury in ex vivo conditions
研究概览
简要总结
This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient scheduled for coronary artery bypass graft surgery and/or aortic valve replacement with extra-corporeal circulation
- •Patient in sinus rhythm at the time of surgery
- •Patient older than 18
- •Patient able to understand the information and consent forms
排除标准
- •Medical history of type 2 diabetes, atrial fibrillation or use of class III anti-arhythmic drug
- •left ventricle ejection fraction < 40%
- •Pregnancy
- •Patient in emergency condition
研究组 & 干预措施
morning group
cardiac surgery scheduled in the morning
干预措施: cardiac surgery scheduled in the morning (Procedure)
afternoon group
cardiac surgery scheduled in the afternoon
干预措施: cardiac surgery scheduled in the afternoon (Procedure)
结局指标
主要结局
ischemia reperfusion injury in ex vivo conditions
时间窗: the day of the myocardial biopsy
measurement of hs troponin T released by the myocardium samples in the superfusion solution after ex vivo conditions mimicking ischemia-reperfusion
次要结局
未报告次要终点