Comparing Intubating Conditions Using Succinylcholine or Rocuronium/Sugammadex for Rigid Bronchoscopy: a Randomized Study
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Intubating Condition
研究概览
简要总结
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM) as well as patient satisfaction for these two muscle relaxants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age > 18 yr
- •scheduled for elective rigid bronchoscopy
排除标准
- •known neuromuscular disease
- •significant hepatic or renal dysfunction
- •family history of malignant hyperthermia
- •known allergy to one of the drugs used in this protocol
- •pregnancy or breastfeeding
研究组 & 干预措施
Succinylcholine
Succinylcholine 0,5mg/kg as muscle relaxant during induction of anaesthesia for rigid bronchoscopy
干预措施: Succinylcholine (Drug)
Rocuronium 0,3
Rocuronium 0,3 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied.
干预措施: Rocuronium 0,3 (Drug)
Rocuronium 0,6
Rocuronium 0,6 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied.
干预措施: Rocuronium 0,6 (Drug)
结局指标
主要结局
Intubating Condition
时间窗: after induction of general anaesthesia (after 3-5 minutes)
The intubating conditions will be measured using the scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting the rigid bronchoscope, vocal cord position and coughing
次要结局
- Postoperative Myalgia(72 hours after intervention)
研究者
Prof. Grietje Beck
Professor Dr. med
Dr. Horst Schmidt Klinik GmbH