Examination of Alzheimer's Disease Biomarkers in Tears and Dry Blood Spots
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- AD related biomarkers in tear fluid
研究概览
简要总结
This study aims to investigate whether biomarkers of Alzheimer's disease can be found in tearfluid, as well as dried bloodspots in patients with Alzheimer's disease, other dementia diagnoses compared to controls.
详细描述
Participants under investigation of a neurodegenerative disease who have a planned lumbar puncture in the Memory clinic will be invited to this study. On the same day of the lumbar puncture, tear fluid and dry blod spots will be collected.
Tear fluid is collected using Shirmer's test. Dried blood spots are obtained by a small prick in the finger with a lancet. The blood droplet is transferred onto a special piece of filter paper, where it dries.
As a sub-study, participants who have provided written consent specifically for this purpose will repeat the test with dried blood spots at home one week after participating in the study. The samples are submitted to the Memory Clinic at the participant's next scheduled appointment.
Tear fluid, dried blood spots, as well as blood and cerebrospinal fluid will be examined for AD-related pathology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inclusion criteria for patients:
- •Lumbar puncture with CSF avaiable for analysis
- •Diagnosis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), Frontotemporal dementia (FTD), vascular dementia (VaD) or Normal pressure hydrocephalus (NPH)
- •Of legal age.
- •Inclusion criteria for controls:
- •Lumbar puncture with CSF avaiable for analysis
- •No neurological disease.
- •Of legal age.
排除标准
- •No lumbar puncture
- •Clinically assessed as unfit to participate in the project.
结局指标
主要结局
AD related biomarkers in tear fluid
时间窗: Two years
Concentrations of AD biomarkers (AB42, AB40, Ptau217, NfL, GFAP) in tear fluid in the AD-group compared to non-AD and controls.
AD related biomarkers in dry blod spots
时间窗: Two years
Concentrations of AD biomarkers (AB42, AB40, Ptau217, NfL, GFAP) in dry blot spots in the AD-group compared to non-AD and controls.
次要结局
- Testing dry blod spots at home(Two years)