Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Change in Keratometric Readings (K1 and K2)
研究概览
简要总结
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments.
The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities.
This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism.
The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality.
This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults of either sex aged >30 to 70 years.
- •Phakic eyes.
- •Primary pterygium, Grade II or Grade III (as per protocol grading).
- •Presence of corneal astigmatism on pre-operative assessment.
- •Scheduled for pterygium excision with conjunctival autograft transplantation at the study site.
- •Able to provide written informed consent and to attend the 1-month postoperative assessment.
排除标准
- •Pseudophakic or aphakic eyes.
- •Recurrent pterygium.
- •Prior keratoplasty or trabeculectomy in the study eye.
- •Keratoconus or other corneal pathologies that can independently induce astigmatism.
- •Lenticular astigmatism or significant lens pathology affecting refraction.
- •Eyes planned for simple pterygium excision without conjunctival autograft.
- •Any ocular condition or systemic illness judged likely to interfere with keratometric or refractive measurements, follow-up, or surgical safety.
结局指标
主要结局
Change in Keratometric Readings (K1 and K2)
时间窗: Baseline (pre-operative) and 1 month post-operative.
Keratometric readings, including the flat meridian (K1) and steep meridian (K2) of the anterior corneal surface, will be measured using a manual keratometer. The mean change in K-readings (measured in diopters) from baseline (pre-operative) to post-operative assessment will be calculated to evaluate corneal curvature improvement following pterygium excision with conjunctival autograft.
次要结局
- Change in Astigmatism(Baseline (pre-operative) and 1 month post-operative.)
研究者
Ayeza Nadeem Butt
Principal Investigator
Mughal Eye Trust Hospital