Precision Neuromodulation in Post-Stroke Aphasia Using TMS
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Accuracy on a picture naming test
研究概览
简要总结
The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).
详细描述
In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors will receive SFA + TMS targeting the precision site, and another group will receive SFA + TMS targeting a control site. The primary outcome will be changes in picture naming accuracy. We expect that excitatory TMS targeting a precision site would result in larger improvements in naming accuracy than TMS targeting a control site. Results will provide the efficacy of precision TMS in post-stroke aphasia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with left hemisphere stroke
- •Consent date >= 1 month after stroke onset
- •Fluent in English
- •18 years of age or older
排除标准
- •Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
- •Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
- •A chronic medical condition that is not treated or is unstable
- •The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)
- •Pregnancy
- •History of skull fractures, or skin diseases
- •History of ongoing or unmanaged seizures
- •Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
- •History of dyslexia or other developmental learning disabilities
研究组 & 干预措施
Precision TMS
SFA will be administered immediately after precision TMS
干预措施: Precision TMS with SFA (Device)
Control TMS
SFA will be administered immediately after control TMS
干预措施: Control TMS with SFA (Device)
结局指标
主要结局
Accuracy on a picture naming test
时间窗: immediately after and 8-12 weeks after last SFA+TMS treatment
Changes in accuracy on untrained stimuli after SFA+TMS compared between groups (precision, control).
次要结局
未报告次要终点
研究者
Priyanka Shah-Basak, PhD
Assistant Professor
Medical College of Wisconsin