MRI of neurometabolic impairment in ALS and TIA using hyperpolarized pyruvate

Christoffer Laustsen0 个研究点目标入组 46 人开始时间: 2020年2月13日最近更新: 2020年5月11日

试验速览

暂无简介。

•All participants:
•-Aged 18 – 85 years. The age and gender of the healthy controls of the main study will be matched to the patients in ALS and TIA groups
•-Pre-menopausal women must be confirmed non-pregnant by an onsite test
•-Fulfilling the 2015 revised El Escorial criteria
•-Upper motor neuron symptoms
•-TIA within the last 10 days. TIA is defined as symptoms shorter than 24 hours (time definition) with a likely vascular genesis (mimics such as urinary tract infection, hypoglycemia and migraine are excluded)
•-Symptoms must include unilateral weakness of face and/or limb
•-Symptom duration > 10 minutes
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 25
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 21

•Contraindications for MRI with contrast:
•-Chronic kidney disease
•-Significant cardiac disease such as severe left ventricular outflow obstruction
•-Significant obstructive lung disease or severe asthma
•-Pacemaker, neurostimulator or cholera implant
•-Metal foreign bodies such as fragments and irremovable piercings
•-Unsafe medical implants (safety of heart valves, hips and the like must be confirmed)
•-Intracranial clips or coils
•-Claustrophobia
•-Largest circumference including arms > 160 cm
•Competing neurological, psychiatric, liver or systemic disease including diabetes (except prior TIA, unspecific brain MRI findings, hypertension, atherosclerosis and hyperlipidemia/cholesterolemia which are allowed)

发起方

Christoffer Laustsen