Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Change from baseline R5 (airway resistance measured at 5Hz) within 2h after the filtration intervention
研究概览
简要总结
The purpose of this research project is to examine whether short-term use of portable air pollution filtration can result in changes in indoor airborne pollutants and impact on cardiovascular and respiratory health outcomes of the inhabitants.
详细描述
This study will focus on evaluating the short-term benefits of a common portable air purifier technology in reducing air pollutant exposure and the anticipated concomitant health impacts. High ambient levels of various air pollutants in the Shanghai area serve as a useful model to test the portable air purifier intervention in a realistic setting. As most people using a portable air purifier would only be able to do so in their residences, the investigators have designed our study only to test residential air purifier use. Our hypothesis is that the reduction in pollutant concentrations in indoor air caused by the air purifier will result in measurable reductions in risk factors for cardiovascular and respiratory diseases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, non-smoking adults
- •Live in the dormitory building at Shanghai First People's Hospital (South Section).
排除标准
- •Current smokers
- •Has any of the following diseases: chronic respiratory, cardiovascular, liver, renal, hematological disease; diabetes mellitus;
- •Has any other diseases that may confound or complicate the effects of the intervention
- •Pregnant females
结局指标
主要结局
Change from baseline R5 (airway resistance measured at 5Hz) within 2h after the filtration intervention
时间窗: Within 2h after the filtration intervention
R5 (airway resistance measured at 5Hz) was accessed by impulse oscillometry in all subjects within 2h after the filtration intervention to compare to the R5 value of study subjects at baseline (i.e. before the start of intervention).
Change in baseline exhaled nitric oxide (eNO) within 2h after the filtration intervention
时间窗: Within 2h after the filtration intervention
Exhaled nitric oxide (eNO) was measured in all subjects within 2h after the filtration intervention to compare to the exhaled nitric oxide measurement of study subjects at baseline (i.e. before the start of intervention). Exhaled breath is collected in air sampling bags, and the concentration of NO was quantified by Thermo Scientific model 42i (NO-NO2-NOx) analyzer.
Change from baseline PWV (pulse wave velocity) within 2h after the filtration intervention
时间窗: Within 2h after the filtration intervention
PWV (pulse wave velocity) was measured by the VICORDER instrument in all subjects right after filtration intervention to compare to the PWV value measured at baseline (i.e. before the start of intervention).
Change in exhaled nitric oxide (eNO) at 6h after filtration intervention compared to baseline
时间窗: 6h after filtration intervention
Exhaled nitric oxide (eNO) was measured in all subjects 6h after filtration intervention to compare to the exhaled nitric oxide measurement of study subjects at baseline (i.e. before the start of intervention). Exhaled breath is collected in air sampling bags, and the concentration of NO was quantified by Thermo Scientific model 42i (NO-NO2-NOx) analyzer.
Change from baseline FEV1 (forced expiratory volume in the first second of exhalation) within 2h after the filtration intervention
时间窗: Within 2h after the filtration intervention
FEV1 (forced expiratory volume in the first second of exhalation, unit: liter) was measured by spirometry in all subjects within 2h after the filtration intervention to compare to FEV1 value of study subjects at baseline (i.e. at start of the study).
次要结局
- Change from baseline urinary biomarkers of inflammation and oxidative stress at 0h after the filtration intervention(At 0h after the filtration intervention)
- Changes in baseline blood biomarkers of inflammation, oxidative stress and coagulation right after filtration intervention(24h after filtration intervention)
- Change in baseline urinary biomarkers of inflammation and oxidative stress at 6h after filtration intervention(6h after filtration intervention)
- Changes in baseline blood biomarkers of inflammation, oxidative stress and coagulation within 1h after filtration intervention(Within 1h after filtration intervention)
- Change in baseline urinary biomarkers of inflammation and oxidative stress at 24h after filtration intervention(24h after filtration intervention)
- Change in the duration of deep sleep on the first night and the second night of study participation(On the first night and the second night of study participation)
研究者
Feng Li
MD
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine