The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Tracking down the difficulties in metaphor comprehension via task during electrophysiological recording
研究概览
简要总结
Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
详细描述
The investigators will address the following objectives:
- Primary Objective: Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
- Secondary Objectives: 1) Evaluate the interactions between performances in metaphor comprehension and individual differences in psychopathology, cognition, ToM and functioning; 2) Test if the altered neurophysiological patterns associated to the fragility of metaphor comprehension in schizophrenia can be restored through a rehabilitative training
The investigators will enroll 32 schizophrenic patients and 32 healthy subjects as control sample.
Participants will undergo an initial visit with a specialist psychiatrist who will verify that their conditions meet the criteria required by the study. Then, subjects will be tested for metaphor comprehension, as well as for the other variables included in the study, and the electrical brain activity will be registered through a 128 channel EEG.
In the check-up visits (i.e., after the training) the following data will be collected:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For patients:
- •Age between 18 and 65 years
- •Diagnosis of Schizophrenia according to DSM V criteria
- •Ability to provide informed consent
- •For healthy controls:
- •Age between 18 and 65 years
- •Ability to provide informed consent
- •Absence of psychiatric pathologies
- •Ability to speak Italian
排除标准
- •For patients:
- •Intellectual disability
- •Neurological disorder
- •For healthy controls:
- •Presence of psychiatric pathologies
- •Difficulties in speaking Italian
结局指标
主要结局
Tracking down the difficulties in metaphor comprehension via task during electrophysiological recording
时间窗: through study completion, an average of 2 years
Exploring the difference in the neurological correlates (via electrophysiological recording technique) between patients and controls. Electrophysiological indexes that will be evaluated are event-related potential after the stimulus presentation.
Tracking down the difficulties in metaphor comprehension via a behavioural task
时间窗: through study completion, an average of 2 years
Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia compared to healthy controls across different metaphor types through the Physical and mental metaphor task (PMM) (range values 0-28, higher scores mean a better outcome).
次要结局
- Evaluation of functioning(through study completion, an average of 2 years)
- Evaluation of Theory of Mind(through study completion, an average of 2 years)
- Evaluation of psychopathology(through study completion, an average of 2 years)
- Evaluation of cognition(through study completion, an average of 2 years)
- Evaluate the efficacy of a rehabilitative training in restoring metaphor comprehension ability(through study completion, an average of 2 years)