Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 192
- 试验地点
- 1
- 主要终点
- HAM-D 17 Item: Hamilton Depression Rating Scale
研究概览
简要总结
The purpose of the study is to find out what parts of the brain have increased or decreased activity and connectivity in individuals who have bipolar disorder, major depression, or no history of mood disorder. Another purpose of this study is to use MRI images to determine which young adults with major depression may be at greater risk for developing mild or more severe symptoms of mania which suggests a diagnosis of bipolar disorder.
详细描述
The study involves two phases, phase one includes the screening visit and MRI. The second phase, for depression participants, involves in person follow ups for up to two years. The second phase, for healthy and bipolar participants, involves phone follow ups, every three months for up to two years. The purpose of this study is listed above. We plan to enroll 200 participants total.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
High Risk Depression
Interventions will include the prescribing of Selective serotonin reuptake inhibitor or Serotonin-norepinephrine reuptake inhibitor antidepressants, bupropion or other antidepressant.
干预措施: Selective Serotonin Reuptake Inhibitor (SSRI) (Drug)
Low Risk Depression
Interventions will include the prescribing of Selective serotonin reuptake inhibitor or Serotonin-norepinephrine reuptake inhibitor antidepressants, bupropion or other antidepressant..
干预措施: Selective Serotonin Reuptake Inhibitor (SSRI) (Drug)
结局指标
主要结局
HAM-D 17 Item: Hamilton Depression Rating Scale
时间窗: 24 months
Hamilton depression rating scale (17-item HAM-D): Scores can range from 0 to 52: No depression (0-7); Mild depression (8-16); Moderate depression (17-23); and Severe depression (≥24).
次要结局
- YMRS: Young Mania Rating Scale(24 months)