Exploring the Immunology of Sarcoidosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Transcriptomics (RNA) -tissue
研究概览
简要总结
In sarcoidosis, over activity of parts of the immune system drives the accumulation of granulomas (collections of immune cells) in affected parts of the body. To facilitate development of effective and safe treatment options in the future it will be vital to understand how and why the immune system becomes over active. The aim of this research is to work towards this goal by studying cells of the immune system and the molecular pathways inside these cells that control how they behave. This will be achieved by analysing patterns of proteins and RNA (the code used to tell cells which proteins to produce) in immune cells present in blood samples and tissue biopsies from people with sarcoidosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males or females, of any race, between 18 and 85 years of age, inclusive
- •Able to provide written informed consent
- •Clinician diagnosis of sarcoidosis
- •Treatment-naïve or receiving immunomodulatory therapy.
排除标准
- •Evidence of acute bacterial infection or other condition likely in the opinion of the investigator to significantly impact results of blood assays.
结局指标
主要结局
Transcriptomics (RNA) -tissue
时间窗: 3 years
RNA expression and distribution (on different cell types) will be scored quantitatively or semi-quantitatively. Statistical analysis will be descriptive with heat maps for RNA expression (clustered using complete-linkage clustering) and charts (median and interquartile ranges) for comparisons.
次要结局
- Protein - tissue(3 years)
- Transcriptomics (RNA) - blood(3 years)
- Cytokines - blood(3 years)