NL-OMON48148撤回不适用
Effect of sodium oxybate on brown adipose tissue activity in narcolepsy - Sodium oxybate and brown adipose tissue in narcolepsy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. Narcolepsy type 1 based on ICSD-3 criteria.
- •2. *18 and <40 years of age.
- •3. White Caucasian descent.
- •4. Clinical indication for sodium oxybate treatment.
- •5. BMI * 27 kg/m2, Healthy controls:
- •1. Age-, gender- and BMI-match with patient.
排除标准
- •Patients and healthy controls:
- •1. Smoking.
- •2. Renal, hepatic or endocrine disease.
- •3. Previous use of sodium oxybate.
- •4. Use of medication known to influence glucose and/or lipid metabolism or
- •brown adiposue tissue activity (e.g. *-adrenergic receptor blockers).
- •5. Participation in an intensive weight-loss program or vigorous exercise
- •program during the year before the start of the study.
- •6. Contraindications for sodium oxybate treatment.
- •7. Contraindications for undergoing an MRI scan:
- •- Presence of non-MR safe metal implants or objects in the body.
- •- Pacemaker, neurostimulator, hydrocephalus pump, drug pump, non-removable
- •hearing aid, large recent tattoos.
- •- Claustrophobia
- •- Tinnitus or hyperacusis
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