NL-OMON47485已完成不适用
Morphine for palliative treatment of refractory dyspnea in patients with advanced COPD: benefits and respiratory adverse effects - MORDYC
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 124 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 124
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* diagnosis of COPD according to the current Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (GOLD);;* optimal pharmacological treatment including treatment with a combination of a long-acting muscarinic antagonist and an ultra-long-acting *-agonist; ;* Grade 2, 3 or 4 dyspnea on the mMRC; ;* optimal non-pharmacological treatment defined as completed a comprehensive pulmonary rehabilitation program
排除标准
- •* history of substance misuse;
- •* exacerbation of COPD within two weeks of study enrolment;
- •* waiting list for lung transplantation;
- •* pregnant or childbearing potential not using contraception;
- •* renal failure (creatinine clearance <15mL/min);
- •* age under 18
- •* not being able to read or fill in the questionnaires or diary
- •* allergy for morphine or its excipients
- •* concomitant use of irreversible MAO blockers
- •* use of opioids
- •* history of convulsions
- •* head injury
- •* intestinal obstruction
- •* gastroparesis
- •* liver disease
研究者
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