Biological Age as a Prognostic Marker in Hospitalized Patients With Advanced Cancer: A Retrospective Analysis Based on PhenoAge Model
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,615
- 试验地点
- 1
- 主要终点
- 90-Day All-Cause Mortality
研究概览
简要总结
This retrospective study evaluates whether biological age, calculated using the PhenoAge model, predicts short-term outcomes in patients with advanced cancer who were hospitalized. The main goal is to investigate associations between biological age and short-term mortality, functional status (ECOG), comorbidity burden (mCCI), and length of hospital stay. All data were collected from medical records without any patient intervention.
详细描述
This is a retrospective observational study including hospitalized adult patients with stage III or IV solid tumors admitted to Etlik City Hospital between November 5, 2022 and December 31, 2024. Patients were included if they stayed for ≥48 hours and had all required laboratory values for calculating biological age using the Levine PhenoAge model. The study aimed to evaluate the association between biological age and (1) 30- and 90-day mortality, (2) ECOG performance score, (3) modified Charlson Comorbidity Index (mCCI), and (4) hospital length of stay. Regression and survival analyses were used to identify prognostic factors. All data were anonymized and collected retrospectively from hospital records.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized in the Medical Oncology Department between November 5, 2022, and December 31, 2024
- •Histologically confirmed advanced-stage (stage III-IV) solid tumors
- •Age ≥18 years
- •Hospital stay of at least 48 hours
- •Actively receiving chemotherapy or received it within the last 6 months
- •Availability of all 9 required laboratory tests (albumin, creatinine, glucose, CRP, lymphocyte %, MCV, RDW, ALP, WBC) for PhenoAge calculation during the first admission
- •Patients with multiple hospitalizations who meet the inclusion criteria will be included
排除标准
- •Elective hospitalizations (e.g., planned chemotherapy, biopsy)
- •Patients who died during the first admission
- •Missing required laboratory parameters
- •ICU patients and unconscious patients
结局指标
主要结局
90-Day All-Cause Mortality
时间窗: Up to 90 days post-admission
All-cause mortality within 90 days following the date of hospital admission (index hospitalization).
次要结局
- Modified Charlson Comorbidity Index (mCCI)(Baseline (Day of hospital admission))
研究者
Galip Can Uyar
MD
Ankara Etlik City Hospital