NCT01042626已完成不适用
Dissimilar PTH, Gastrin, and Ionized Calcium Response to Oral Peptones in Normocalcemic Primary Hyperparathyroidism, Hypercalcemic Primary Hyperparathyroidism and Healthy Subjects
University of Eastern Piedmont2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2004年7月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- PTH levels variations
研究概览
简要总结
The purpose of this study is to assess if subjects with hyperparathyroidism with normal serum calcium levels have different responses in the calcium regulating hormonal handling compared to a) patients with primary hyperparathyroidism and high serum calcium levels; b) healthy subjects.
The differences will be evaluated with oral peptones load and subsequent blood samples collected every 15 minutes for two hours. Ionized calcium, phosphate, gastrin and PTH levels will be evaluated.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •normocalcemic hyperparathyroidism
- •presence of high serum levels of intact PTH
- •serum ionized calcium levels in the high normality range
- •hypercalcemic hyperparathyroidism
- •presence of high serum levels of intact PTH
- •high serum ionized calcium levels
排除标准
- •potential causes of secondary hyperparathyroidism like renal insufficiency, liver disease, malabsorption, hypercalciuria, Paget's disease, thiazide diuretic or lithium use.
- •bone disease of any origin
结局指标
主要结局
PTH levels variations
时间窗: 2 hours
Ionized serum calcium variations
时间窗: 2 hours
Serum phosphate variations
时间窗: 2 hours
Serum gastrin variations
时间窗: 2 hours
次要结局
未报告次要终点
研究者
研究点 (2)
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