Acute And Chronic Effects Of Combined Strength Training On Regulatory Variables Of Ambulatory Blood Pressure In Medicated Hypertensive Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
研究概览
简要总结
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy. It is currently endorsed by treatment and prevention guidelines for systemic arterial hypertension (SAH) due to its significant effect on lowering blood pressure (BP). However, when comparing BP reduction values, isometric strength training (IST) stands out with greater magnitudes of BP reduction, although without the neuromuscular adaptations seen in DST. Given their similarities, a combination of these strategies through combined strength training (CST) is possible but has not yet been evaluated. The researchers hypothesized that CST may have an additive effect compared with DST and IST alone in reducing ambulatory BP. Therefore, the objective of the present thesis was to evaluate and compare the effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients. This thesis is structured in two parts: (1) a crossover study with medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses related to ambulatory BP after a single session of CST, DST, and IST; and (2) a randomized clinical trial to assess the chronic effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients.
详细描述
"This thesis is structured in two sequential stages:
A randomized crossover trial involving medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses on ambulatory blood pressure following a single session of Combined Strength Training (CST), Dynamic Strength Training (DST), and Isometric Strength Training (IST), compared to a control session.
A randomized controlled trial to assess the chronic effects (8 weeks) of CST and DST on the regulatory variables of ambulatory blood pressure in medicated middle-aged hypertensive patients, compared to a non-exercising control group."
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
While it was not possible to mask the participants and the exercise instructors due to the nature of the training sessions, a clear separation was maintained between the team supervising the exercises and the team responsible for data collection and analysis. Specifically, the outcomes assessors responsible for the Ambulatory Blood Pressure Monitoring (ABPM) and Flow-Mediated Dilation (FMD) measurements were completely blinded to the participants' group allocation and had no involvement in the training protocols.
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of stage 1 or stage 2 hypertension, according to current guidelines.
- •Sedentary lifestyle (no participation in structured exercise training for at least 6 months).
- •Age between 18 and 60 years. Stable antihypertensive pharmacological treatment for at least 4 weeks before enrollment.
- •Ability to perform resistance exercise.
排除标准
- •Symptomatic cardiovascular disease. Heart failure. Unstable angina. Uncontrolled diabetes mellitus (HbA1c > 8%). Renal insufficiency. Musculoskeletal disorders or physical limitations that contraindicate resistance exercise.
- •Changes in antihypertensive medication within the 4 weeks prior to enrollment or during the study protocol.
- •Current smoking. Excessive alcohol consumption.
研究组 & 干预措施
Isometric strength training
8 isometric strength exercises. 10 seconds of isometric strength. 3 sets, 1 second concentric and 2 eccentric. 30 seconds rest between sets and 1 minute and 30 seconds rest between exercises.
干预措施: Acute Isometric Exercise Session. (Other)
Control group
The control group consists of maintaining their habits for 8 weeks, without strength exercises.
干预措施: Control Session and Follow-up (Other)
Combined strength training
8 resistance exercises combining dynamic repetitions with isometric components. Protocol: 3 sets of 11 repetitions, with a concentric phase of 1 second and an eccentric phase of 2 seconds combined with 10 seconds of isometric hold at the end of each set. Includes 30 seconds of rest between sets and 90 seconds between exercises.
干预措施: Combined strength training (Other)
Dynamic strength training
8 dynamic strength exercises, with 14 repetitions, 3 sets, 1 second concentric phase and 2 seconds eccentric phase. 30 seconds of rest between sets and 1 minute and 30 seconds of rest between exercises.
干预措施: Dynamic strength training (Other)
结局指标
主要结局
24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
时间窗: Baseline and 8 weeks
Average systolic blood pressure measured over a 24-hour period using an automated ambulatory monitor (ABPM). This measure assesses the chronic effect of the 8-week training protocols compared to baseline.
次要结局
- Acute 24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)(24 hours post-intervention)
- Acute Post-Exercise Blood Pressure Response(Baseline, 30 minutes, and 60 minutes post-exercise.)
- Vascular Endothelial Function - Chronic (Flow-Mediated Dilation)(Baseline and 8 weeks)
- Vascular Endothelial Function - Acute Response (Flow-Mediated Dilation)(Baseline, 30 minutes, and 60 minutes post-exercise.)
- Cardiac Autonomic Modulation - Chronic (Heart Rate Variability)(Baseline and 8 weeks.)
- Cardiac Autonomic Modulation - Acute Response (Heart Rate Variability)(Baseline, 30 minutes, and 60 minutes post-exercise.)
- Office Blood Pressure Adaptation (Weekly Progression)(Baseline and weekly for 8 weeks.)
- Blood-based Biomarkers of Cardiovascular Health(Baseline and 8 weeks)
- Acute Blood-based Biomarkers Response(Baseline, 30 minutes, and 60 minutes post-exercise.)
- Body Composition (Skinfold Thickness)(Baseline and 8 weeks)
研究者
Alvaro Reischak-Oliveira
Professor at Universidade Federal do Rio Grande do Sul
Federal University of Rio Grande do Sul