The Effect of Brain Anatomy on the Efficacy of Brain Stimulation Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in Corticomotor Excitability With Sham Stimulation on Finger Muscle
研究概览
简要总结
The purpose of this research study is to determine whether brain anatomy impacts the efficacy of transcranial magnetic stimulation (TMS) which is a form of non-invasive brain stimulation. TMS is used to stimulate different areas of the brain and it is well tolerated and generally a safe procedure. It has been studied by researchers for 20 plus years. This brain stimulation device and technique used in this study is an investigational device that has not been approved by the U.S. FDA for treating any muscle or nerve problems. A copy of the device brochure can be found at: https://www.magstim.com/product/rapid-family/
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Participants will not be able to tell the difference if they are being given active vs sham stimulation but will receive both.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •nonimpaired individuals
- •free of contraindications for MRI and TMS
排除标准
- •musculoskeletal injury of the arm
- •neurologic deficit affecting motor or sensory function
- •concurrent severe medical illness
- •diagnosis of SARS-CoV2, or symptoms consistent with COVID-19, or close contact with someone with SARS-CoV2 in the past 3 weeks
研究组 & 干预措施
Brain stimulation over bicep muscle than finger (FDI) muscle.
Brain stimulation will occur over two sessions. Both sessions will occur with sham stimulation then active stimulation. There will be a 3 day rest period between the two muscle groups.
干预措施: intermittent theta burst stimulation (iTBS) with sham and then active stimulation over bicep muscle (Device)
Brain stimulation over bicep muscle than finger (FDI) muscle.
Brain stimulation will occur over two sessions. Both sessions will occur with sham stimulation then active stimulation. There will be a 3 day rest period between the two muscle groups.
干预措施: intermittent theta burst stimulation (iTBS) with sham and then active stimulation over finger muscle (Device)
Brain stimulation over than finger (FDI) muscle than bicep muscle.
Brain stimulation will occur over two sessions. Both sessions will occur with sham stimulation then active stimulation. There will be a 3 day rest period between the two muscle groups.
干预措施: intermittent theta burst stimulation (iTBS) with sham and then active stimulation over bicep muscle (Device)
Brain stimulation over than finger (FDI) muscle than bicep muscle.
Brain stimulation will occur over two sessions. Both sessions will occur with sham stimulation then active stimulation. There will be a 3 day rest period between the two muscle groups.
干预措施: intermittent theta burst stimulation (iTBS) with sham and then active stimulation over finger muscle (Device)
结局指标
主要结局
Change in Corticomotor Excitability With Sham Stimulation on Finger Muscle
时间窗: approximately 7 days
The amplitude the motor evoked potentials (MEPS) will be used to determine level of corticomotor excitability
Change in Corticomotor Excitability With Active Stimulation on Finger Muscle
时间窗: approximately 7 days
The amplitude the motor evoked potentials (MEPS) will be used to determine level of corticomotor excitability
Change in Corticomotor Excitability With Active Stimulation on Bicep Muscle
时间窗: approximately 7 days
The amplitude the motor evoked potentials (MEPS) will be used to determine level of corticomotor excitability
Change in Corticomotor Excitability With Sham Stimulation on Bicep Muscle
时间窗: approximately 7 days
The amplitude the motor evoked potentials (MEPS) will be used to determine level of corticomotor excitability
次要结局
未报告次要终点